The study also showed that a higher level of the metabolic signature was associated with a lower long-term risk of CVD among PREDIMED study participants. Even after accounting for traditional CVD risk factors, the metabolic signature was effective at predicting long-term risk of CVD, the researchers said.The researchers further tested and verified the metabolic signature in blood samples from 6,868 participants from the U.S.-based Nurses\u2019 Health Study, Nurses\u2019 Health Study II, and Health Professional\u2019s Follow-Up Survey. They noted that ability for the signature to determine adherence and metabolic response to the Mediterranean diet, and to predict future CVD risk, were highly reproducible across all the study populations despite the fact that individuals living in Spain and in the U.S. have different dietary habits, lifestyles, and environmental exposures.\u201cThis study is the first to develop a metabolic signature for the Mediterranean diet based on comprehensive metabolomic profiles. It demonstrates that the level of dietary adherence and individual\u2019s response to diet can be objectively measured,\u201d said\u00a0Liming Liang<\/a>, associate professor of epidemiology and biostatistics at Harvard Chan School and co-senior author of the paper.<\/p>\n The reproducibility of the findings in the U.S. and Spanish populations indicate the robustness of the approach. Assessing adherence to the Mediterranean diet has often relied on self-reported data obtained through questionnaires of study participants. The\u00a0newly discovered metabolic signature could prove to be a potent and objective tool for the research community to further evaluate individuals\u2019 adherence and metabolic response to the Mediterranean diet in various study populations and settings. The metabolic signature and metabolites included in the signature could also help researchers better understand how the Mediterranean diet can benefit people with complex metabolic diseases.<\/p>\n Given that the metabolic signature is reflective of individuals\u2019 metabolic response to diet and CVD risk, the signature has potential in the future to help facilitate personalized nutrition interventions.\u201d\u201cFrom a public health perspective, our findings underscored the beneficial effects of the Mediterranean diet for the prevention of cardiovascular disease at a molecular level.<\/p>\n Researchers from the Spanish PREDIMED study group (URV and UN), Brigham and Women\u2019s Hospital, and the Broad Institute of MIT and Harvard were also co-authors of the paper.<\/p>\n Reference: Jun Li et al. \u201cThe Mediterranean diet, plasma AQ3 metabolome, and cardiovascular disease risk\u201d European Heart Journal (2020) 00, 1\u201313 Clinical Research. doi:10.1093\/eurheartj\/ehaa209<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" A newly identified \u201cmetabolic signature\u201d can evaluate an individual\u2019s adherence and metabolic response to the Mediterranean diet and help predict future risk of developing cardiovascular disease (CVD), according to new research led by Harvard University with collaborators from the Broad Institute and Universitat Rovira i Virgili<\/p>\n","protected":false},"author":4,"featured_media":73689,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[806,3476,3460,790,82,236,3848,818,195],"tags":[],"class_list":["post-73791","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-communicating-science","category-biochemistry-biotechnology","category-departments","category-faculty-medicine","category-general-en","category-health","category-human-nutrition","category-press-releases","category-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/posts\/73791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/comments?post=73791"}],"version-history":[{"count":0,"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/posts\/73791\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/media\/73689"}],"wp:attachment":[{"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/media?parent=73791"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/categories?post=73791"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diaridigital.urv.cat\/en\/wp-json\/wp\/v2\/tags?post=73791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"http:\/\/diaridigital.urv.cat\/wp-content\/uploads\/2017\/09\/foto2.png\")
<\/a>