09/03/2017

Physical inactivity and sedentary behaviors are associated with cardiometabolic risk factors

Greater time spent in physical activities with moderate-high intensity and less time devoted to sedentary activities, such as watching television, are associated with a lower presence of cardiometabolic risk factors including obesity, diabetes and certain individual components of metabolic syndrome, according to the first results published from the multicentric study PREDIMED-PLUS

The results are from the first investigation to be conducted with baseline data from the PREDIMED-PLUS study, an 8-year multicenter clinical trial based on a nutritional intervention involving an energy-restricted Mediterranean diet, the promotion of physical activity and behavioral support for primary cardiovascular prevention. The study is taking place nationwide across Spain and started in October 2013.

Previous studies of healthy adults and persons with diabetes have demonstrated that physical activity – particularly activities with moderate-high intensity – and daily sedentary behaviors, such as watching television, have a significant effect on cardiometabolic health. Nevertheless, these observations have never been explored in older adults at high cardiovascular risk, a typically sedentary and physically inactive population that has a high risk of developing chronic diseases.

Consequently, the Human Nutrition Unit of the Universitat Rovira i Virgili has joined forces with 22 other Spanish centers to implement the PREDIMED-PLUS trial and thus address this question by evaluating different types of physical activities and sedentary behaviors in a population of 5,576 men and women with high cardiovascular risk. They have also studied the effect of replacing the time spent watching television with the same time engaging physical activities with different intensities.

The most striking results from this investigation show that increasing the time spent on physical activities with moderate-high intensity (brisk walking, climbing stairs, working in the garden or performing sports) by one hour a day was associated with a 3%-6% increase in protection against obesity, diabetes, abdominal obesity and low HDL-cholesterol. In contrast, increasing the time spent watching television by one hour a day was associated with an increased presence of these cardiometabolic risk factors. Moreover, when one hour a day of watching television was replaced by one hour a day of physical activity with moderate-high intensity, the protection against these cardiometabiloc risk factors was even greater (3%-9%) than the protection observed when each activity was evaluated separately.

PREDIMED-PLUS es un ensayo clínico multicéntrico de 8 años basado en una intervención nutricional con dieta mediterránea hipocalórica, promoción de la actividad física y soporte conductual para la prevención primaria cardiovascular.

These results show that public health strategies aimed at preventing cardiometabolic diseases are of paramount importance among adults aged 55-60. These strategies should focus on promoting physical activities with moderate-high intensity, avoiding sedentary behaviors and replacing the time spent on sedentary activities with time spent on other more active pursuits.

The current investigation has been carried out by Núria Rosique-Esteban and Dr Andrés Díaz-López, both investigators at the URV’s Human Nutrition Unit, and led by Jordi Salas-Salvadó, professor and director of the Unit, Head Clinician at the Sant Joan University Hospital of Reus, and Principal Investigator at CIBERobn at the Carlos III Institute of Health. All three are also members of the Pere Virgili Institute of Health Research (IISPV). The study has been published in the scientific journal PLOS ONE (http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172253) in March 2017.

This article is the result of the first investigation within the PREDIMED-PLUS consortium. The final results of the whole trial will be ready by 2020 and are eagerly awaited by the scientific community.

 Bibliography: Rosique-Esteban N, Díaz-López A, Martínez-González MA, Corella D, Goday A, Martínez JA, Romaguera D, Vioque J, Arós F, Garcia-Rios A, Tinahones F, Estruch R, Fernández-García JC, Lapetra J, Serra-Majem L, Pinto X, Tur JA, Bueno-Cavanillas A, Vidal J, Delgado-Rodríguez M, Daimiel L, Vázquez C, Rubio MA, Ros E and Salas-Salvadó J. Leisure-time Physical Activity, Sedentary Behaviors, Sleep, and Cardiometabolic Risk Factors at Baseline in the PREDIMED-PLUS Intervention Trial: a Cross-Sectional Analysis. PLOS ONE, Mar 2017 DOI: 10.1371/journal.pone.0172253


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